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CFR - Code of Federal Regulations Title 21
Filtered by:. Previous 1 2 template Next. Video Man. Now I can't find it; the local orange big-box has a "MEK subsitute. Did they take it off the market or something? Tags: None. Mike P. I just saw MEK at the paint store the other day. I don't think it said "substitute" on it. Comment Post Cancel. Lew Hartswick. I'm sure I've seen it at Lowes within the last month.
Tony Wells. Sherwin-Williams R6K10 still available. Scientists have shown that the moon is moving away at a tiny yet measurable distance from the earth every year. If you do the math, you can calculate that 85 million years ago the moon was orbiting the earth at a distance of about 35 feet from the earth's surface. This would explain the death of the dinosaurs. The tallest ones, anyway. Should be lots of MEK in Florida!Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed.
More information about the EC Inventory can be found here. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance.
If generated, an InChI string will also be generated and made available for searching. More help available here. CAS no. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The source of the information is mentioned in the introductory sentence of the hazard statements. When information is available in all sources, the first two are displayed as a priority. The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format.
It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration e. Other relevant information includes the following:.
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. If the substance is covered by more than one CLH entry e. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation.
More info on CLH can be found here. This information has not been reviewed or verified by ECHA, and may change without prior notice. These notifications can be provided by manufacturers, importers and downstream users.
According to the harmonised classification and labelling CLP00 approved by the European Union, this substance is a highly flammable liquid and vapour, causes serious eye irritation and may cause drowsiness or dizziness. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. The use information is displayed per substance life cycle stage consumer use, in articles, by professional workers widespread usesin formulation or re-packing, at industrial sites or in manufacturing.
The information is aggregated from the data coming from REACH substance registrations provided by industry. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.
Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R. The examples provided are generic examples and may not apply to the specific substance you are viewing.
A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. Furthermore, some substances can be found in an article, but with unlikely exposure e. The described Product category i. More help is available here. This substance is used by consumers, by professional workers widespread usesin formulation or re-packing, at industrial sites and in manufacturing. This substance is used in the following products: lubricants and greases, coating products, anti-freeze products, adhesives and sealants and polishes and waxes.
Other release to the environment of this substance is likely to occur from: outdoor use as processing aid, indoor use e.
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
This substance is used in the following products: coating products, pH regulators and water treatment products, laboratory chemicals and lubricants and greases. This substance is used in the following areas: health services, scientific research and development and printing and recorded media reproduction.ACC is investing in research to improve understanding of how chemicals impact health and the environment.
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A blog of the American Chemistry Council: driving innovation, creating jobs, and enhancing safety. MEK is a liquid solvent used in surface coatings, adhesives, printing inks, chemical intermediates, magnetic tapes and lube oil dewaxing agents.
MEK also is used as an extraction medium for fats, oils, waxes and resins. It is a highly efficient and versatile solvent for surface coatings. Because of its effectiveness as a solvent, MEK is especially valuable in formulating high solids coatings, which help to reduce emissions from coating operations.
Methyl Ethyl Ketone
MEK is a natural component of many foods, including apple juice, beans, chicken, honey and a variety of cheeses. Synonyms for MEK are 2-butanone, ethyl methyl ketone, and methyl acetone. The panel, with the U. Petitions to remove a substance from the HAP list are authorized under Section b 3. EPA determined that ambient concentrations, bioaccumulation, or deposition of MEK may not reasonably be anticipated to cause adverse human health or environmental effects.
The panel's delisting petition presented extensive information on MEK's potential health and environmental effects, environmental releases, and resulting ambient air concentrations.
Methyl Ethyl Ketone
Air dispersion modeling results showed that ambient concentrations of MEK, even at the highest fenceline levels are below levels of concern. Facilities are no longer required to report releases of and other waste management information on MEK.
The purpose of the review was to determine whether existing data are adequate to characterize the risks of MEK to children, and if not, to identify data needs.
No data needs were identified by any of the review committee members. View our resource center to find press releases, testimonies, infographics and more.
The business of chemistry providesskilled, good-paying American jobs. News View our resource center to find press releases, testimonies, infographics and more. Jobs The business of chemistry providesskilled, good-paying American jobs.It can be harmful to the eyes, skin, and if inhaled or swallowed. Workers may be harmed from exposure to methyl ethyl ketone. The level of exposure depends upon the dose, duration, and work being done.
Methyl ethyl ketone is used in many industries. It is used as a solvent and in the manufacture of synthetic rubber, paraffin wax, and to make other chemical products.
Some examples of workers at risk of being exposed to methyl ethyl ketone include the following:.
If you work in an industry that uses methyl ethyl ketone, please read chemical labels and the accompanying Safety Data Sheets for hazard information. The following resources provide information about occupational exposure to methyl ethyl ketone.
Search the HHE database for more information on methyl ethyl ketone. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Section Navigation. Methyl Ethyl Ketone. Minus Related Pages. On This Page. Overview CAS No. Manual of Analytical Methods. Health Hazard Evaluations. Selected Publications Occupational Safety and Health Guidelines for 2-Butanone —Occupational safety and health guidelines that summarizes pertinent information about ethylene glycol for workers, employers, and health professionals.
Volatile Organic Compounds Screening No.
Related Topics All Chemical Topics.To extend follow-up of 14, workers from toand evaluate mortality risk from exposure to trichloroethylene TCE and other chemicals. Multivariable Cox models were used to estimate relative risk for exposed vs.
Exposure-response gradients for TCE were relatively flat and did not materially change since Statistically significant excesses were found for several chemical exposure subgroups and causes, and were generally consistent with the previous follow up. Patterns of mortality have not changed substantially since While positive associations with several cancers were observed, and are consistent with the published literature, interpretation is limited due to the small numbers of events for specific exposures.
Currently, the only organic solvent classified as a human carcinogen is benzene, although others including trichloroethylene, perchloroethylene, chloroform and carbon tetrachloride are labeled as possible or probable carcinogens. In occupational cohort studies, the cancers most often linked to TCE are those of the liver and kidney and non-Hodgkin's lymphoma 56 Some investigators have reported statistically significant increased risks for liver cancer, 8 — 10 kidney cancer 10 — 12 and non-Hodgkin's lymphoma, 81013 although others have not.
Interpretation is further complicated because of the use of different study designs, exposure assessment techniques, reference groups, statistical methods and outcome measures e. The inability to draw strong conclusions has fueled the debate as to whether or not TCE causes cancer. In this present study, we extend the follow up of the Hill Air Force Base cohort through to gain additional information about the health risks associated with workplace exposure to TCE and other solvents and chemicals.
The Hill Air Force Base occupational cohort has been described in detail previously. The cohort is composed of 14, civilians employed at this aircraft maintenance facility for at least one year between 1 January and 31 December Data on date of birth, race and gender and a complete work history at the base were extracted from the personnel records.
Data were also collected from death records on the date and cause of death, which was coded according to the Eighth Revision of the International Classification of Diseases ICDA The exposure assessment that was carried out for this cohort study has been described in detail previously. Walk through surveys and interviews of long term employees were also conducted. Due to limited data linking historic air monitoring and chemical use with specific organizations i.
The specific solvents evaluated were: TCE, 1,1,1-trichloroethane, methylene chloride, carbon tetrachloride, freon, isopropyl alcohol, acetone, toluene, methyl ethyl ketone, O-dichlorobenzene, perchloroethylene, chloroform, Stoddard solvent, and xylene.
Methyl ethyl ketone peroxide
For TCE a more detailed approach was also taken that identified the frequency and pattern of exposure based on the job tasks. Intermittent or continuous exposure was assigned to subjects who used TCE infrequently or regularly, respectively, throughout the day. Low or peak exposure was assigned to subjects who used TCE for bench top work to clean small parts or who worked with vapor degreasers, respectively.
Four categories of TCE were then developed for each worker: low intermittent, low continuous, peak infrequent and peak frequent. From these, a cumulative exposure score for TCE was developed for each subject in each job, summed across all jobs. The NDI is a central computerized index of death record information for the entire US, beginning with deaths reported in The cohort was matched to the NDI using available personal identifiers i.
The previous studies of the cohort by Spirtas et al. As recommended in the literature, we selected age as the time variable in the Cox model since disease and death rates usually change rapidly with age, and age effects should be controlled as precisely as possible.
Blair et al. The Poisson and Cox proportional hazards regression models are similar with the major difference being that the former usually has only a few strata where the latter creates a stratum for each case.
To evaluate exposure-response, we ran the Cox model with the TCE cumulative exposure score. We also ran the model for the specific patterns of exposure that had been used in calculating the TCE cumulative exposure score: low exposure intermittent, continuous and peak exposure infrequent, frequent.
All personal identifiers within the final analytic datafile were deleted and destroyed prior to conducting statistical analyses to protect confidentiality. As in the previous studies of the cohort by Spirtas et al. As of 31 December8, subjects had died and the mean age of the 5, Table 1 provides the results for TCE exposure for follow up throughcomparing the Poisson model rate ratios as reported by Blair et al.
To facilitate comparison, we report the hazard ratios for the follow up using one decimal place as was done with the rate ratios in Blair et al. Differences of at least 0. These differences in point estimates, which could be attributable to either a slight variation in case definition or how the models handle small numbers of events across covariates, are minor when considered in the context of the wide confidence intervals.NCBI Bookshelf.
More than 15 methods to measure methyl isobutyl ketone in different environments are available.
Although sampling and extraction techniques differ, all methods involve gas chromatography. Both methodsIssue 2 andIssue 1 use gas chromatography with a flame ionization detector. Acetone is treated with barium hydroxide to yield diacetone alcohol, which is dehydrated to mesityl oxide, which in turn is hydrogenated to saturate the double bond and produce methyl isobutyl ketone.
Methyl isobutyl ketone can also be prepared by reacting sodium acetoacetic ester with isopropyl bromide and treating the resulting 2-isopropyl acetoacetic ester with diluted acid to saponify the ester and decarboxylate the resulting keto acid NTP, Methyl isobutyl ketone is used primarily as a denaturant and solvent in cosmetic products, in denatured alcohol, and as an excipient in drugs. It is also used as a component of synthetic flavouring substances and adjuvants, and as a component of adhesives that are present in articles intended for use in packaging, transporting or holding food HSDB, Methyl isobutyl ketone is also considered to be an excellent solvent for resins used in the production of surface coating and is widely used in rubber chemicals for the production of tyres.
HSDB, Methyl isobutyl ketone is also used as a solvent in paint and lacquers IPCS, The most probable routes of exposure in the workplace are by inhalation of vapours and by skin and eye contact during the production and use of methyl isobutyl ketone and products in which it is a constituent.
Exposure to methyl isobutyl ketone during spray painting was found to be 0. In a study of workers in two factories in Taipei, mean concentrations of methyl isobutyl ketone in the air samples of solvent-exposed workers were 2 ppm range, 0—68 ppmwhile the mean exposure of spray painters in painting booths was 76 ppm range, 8— ppm Chen et al. In a study among solvent-exposed workers, a mean exposure of Among a group of 27 furniture-makers exposed to a mixture of methyl isobutyl ketone, methyl ethyl ketone, acetone, toluene, xylene, ethylbenzene, butyl acetate, and isobutyl acetate, the TWA concentration of each solvent was below the corresponding occupational exposure limit.
Arithmetic mean exposure to methyl isobutyl ketone was 1. A linear relationship between exposure and urinary concentration was found Kawai et al.
The most probable routes of exposure to methyl isobutyl ketone by the general population are ingestion of contaminated drinking-water and dermal contact with consumer products of which it is a constituent Johnson, Dietary sources of exposure are: natural occurrence in food, addition to food as a flavouring, and migration into food from food packaging. Methyl isobutyl ketone has also been detected in human breast milk Pellizzari et al. Methyl isobutyl ketone was reported to occur naturally in orange and lemon juice, grapes, vinegar, baked potatoes, papaya, ginger, wheat bread, cheeses, milk, cooked eggs, roast chicken, cooked beef, lamb fat, pork liver, hop oil, beer, cognac, coffee, tea, plumcot, plum brandy, mushrooms, trassi, sesame seed, buckwheat, wort, elder flowers, Bourbon vanilla, clary and red sage, crabs, clams, and Chinese quince Burdock, Methyl isobutyl ketone is permitted as a flavouring agent in the USA, where it is considered as safe at current levels of intake.
Usual reported levels ranged from 2. More recently individual intake was estimated at 0. Methyl isobutyl ketone is used in packaging materials that come into contact with food. Levels reported in foods from packaging are: baked goods, Release of methyl isobutyl ketone into the atmosphere may occur during its production through fugitive emissions and incomplete removal of vapours from reaction gases before they are vented or disposed of in a scrubber.
In addition, methyl isobutyl ketone has frequently been identified in leakages from landfills and could potentially contaminate groundwater Francis et al. Another source of environmental contamination is the release of methyl isobutyl ketone during the discharge of spent scrubbing water from industrial production processes IPCS, Methyl isobutyl ketone has been listed by the Council of Europe in category B flavouring substances for which further information is required before the Committee of Experts is able to offer a firm opinion on the safety of their use; these substances can be used provisionally in foodstuff Council of Europe, Methyl isobutyl ketone is listed in the EU database for cosmetic ingredients with the following functions: denaturant, solvent and perfume European Commission, online.
Short-term and 8-hour limit values for methyl isobutyl ketone are given in Table 1. The carcinogenicity studies reviewed below are limited to those of inhalation exposure of mice and rats to methyl isobutyl ketone that were adequately conducted by the National Toxicology Program NTP, ; Stout et al.mek
Treatment-related increases in the incidence of liver tumours hepatocellular adenoma and carcinoma combined were observed in males and females, together with concurrent treatment-related increases in the incidence of eosinophilic foci in the liver.This colorless liquid ketone has a sharp, sweet odor reminiscent of butterscotch and acetone.
It is produced industrially on a large scale, and also occurs in trace amounts in nature.
Butanone may be produced by oxidation of 2-butanol. The dehydrogenation of 2-butanol using a catalyst is catalyzed by copperzincor bronze :. This is used to produce approximately million kilograms yearly. Other syntheses that have been examined but not implemented include Wacker oxidation of 2-butene and oxidation of isobutylbenzenewhich is analogous to the industrial production of acetone.
Both liquid-phase oxidation of heavy naphtha and the Fischer-Tropsch reaction produce mixed oxygenate streams, from which 2-butanone is extracted by fractionation. Butanone is an effective and common solvent  and is used in processes involving gumsresinscellulose acetate and nitrocellulose coatings and in vinyl films. It has similar solvent properties to acetone but boils at a higher temperature and has a significantly slower evaporation rate.
Butanone is also used in dry erase markers as the solvent of the erasable dye. As butanone dissolves polystyrene and many other plastics, it is sold as "model cement" for use in connecting parts of scale model kits.
Though often considered an adhesiveit is actually functioning as a welding agent in this context. Butanone is the precursor to methyl ethyl ketone peroxidewhich is a catalyst for some polymerization reactions such as crosslinking of unsaturated polyester resins. Dimethylglyoxime can be prepared from butanone first by reaction with ethyl nitrite to give diacetyl monoxime followed by conversion to the dioxime: .
In the Peroxide process on producing hydrazinethe starting chemical ammonia is bonded to butanone, oxidized by hydrogen peroxide, bonded to another ammonia molecule. In the final step of the process, a hydrolysis produces the desired product hydrazine and regenerates the butanone. Butanone can react with most oxidizing materials, and can produce fires. Butanone is a constituent of tobacco smoke.
As of [update]some reviewers advised caution in using butanone because of reports of neuropsychological effects. Emission of butanone was regulated in the US as a hazardous air pollutantbecause it is a volatile organic compound contributing to the formation of tropospheric ground-level ozone.
From Wikipedia, the free encyclopedia. MEK . Butanone . CAS Number. Interactive image Interactive image. Beilstein Reference. Gmelin Reference. PubChem CID. Chemical formula. Solubility in water. Refractive index n D. Dipole moment. GHS hazard statements. GHS precautionary statements. Autoignition temperature. LD 50 median dose. LC 50 median concentration.